Review of Traditional Chinese Medicine Treatment of Alzheimer's Disease Based on Turbidity Theory:Focusing on Brain Cholesterol Homeostasis
10.11842/wst.20230719009
- VernacularTitle:基于浊邪理论述评阿尔茨海默病的中医治疗:聚焦脑胆固醇稳态
- Author:
Xueqing DUAN
1
;
Shaofeng WANG
;
Keshangjing WU
;
Jiaxin LI
;
Yanwei HAO
;
Li LI
;
Bin LI
Author Information
1. 成都中医药大学附属医院 成都 610075
- Keywords:
Alzheimer's disease;
Cholesterol homeostasis;
Turbidity;
Traditional Chinese medicine treatment
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2024;26(4):902-907
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD),the most common progressive neurodegenerative disease in dementia,is also a special lipid disease.From the perspective of modern medicine,cholesterol homeostasis is an important risk factor for AD.Amyloid-beta plaque deposition,neurofibrillary tangles,and large amount of lipid granule accumulation are typical pathological features of AD.From the perspective of TCM,turbidity is the key to the pathogenesis of AD.Phlegm turbid,stasis turbid and turbid toxin are the concrete derivation of turbidity,which are the standard of AD.Cholesterol is the greasy lipid which is produced from of the essence of water and food,the disturbance of cholesterol homeostasis is a typical embodiment of the pathogenesis mechanism of endogenous turbidity.Regulating cholesterol homeostasis by traditional Chinese medicine may be a new direction for the treatment of AD in the future.Focusing on the modern research of cholesterol homeostasis,taking the theory of turbidity as the starting point,this paper analyzed the correlation between the connotation of turbidity theory and the imbalance of cholesterol homeostasis as well as the pathogenesis mechanism,and further elucidated the clinical application results in the treatment of AD from the aspects of phlegm turbid,stasis turbid and turbid toxin,so as to better guide clinical practice and scientific research.
