Research Progress on the Application of SAMP8 Mice in Anti-Dementia of Traditional Chinese Medicine
- VernacularTitle:SAMP8小鼠在中医药抗痴呆中的应用研究进展
- Author:
Guoqing WU
1
;
Yushan GAO
;
Zidong WANG
;
Zhigang LI
Author Information
- Keywords: Senescence accelerate mouse prone; Behavioral; Pathological changes; Alzheimer's disease; Review
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(4):886-894
- CountryChina
- Language:Chinese
- Abstract: The senescence accelerate mouse prone are a model of early learning and memory impairment,because they exhibit most of the characteristics of the pathogenesis of Alzheimer's disease,including abnormal expression of anti-aging factors,excessive increase of inflammatory factors,amyloid deposition,tau protein hyperphosphorylation,mitochondrial autophagy,the central mechanism of blood-brain barrier damage,and pathological damage of multiple systems and organs.Therefore,it has been widely used as an ideal model for Alzheimer's disease research.With the deepening of the experimental research on the mechanism of AD,it was found that SAMP8 mice showed obvious changes in behavior,histopathology and biochemical parameters compared with SAMR1,which were similar to human diseases.Therefore,this paper reviews the research progress of SAMP8 mice in recent years,in order to provide useful guidance and help for the application of SAMP8 mouse model in a variety of aging diseases.
