A Review and Comment of Animal Models of Spleen Deficiency Syndrome
- VernacularTitle:脾虚证动物模型研究述评
- Author:
Mengxiong LU
1
;
Hong XUE
;
Beihua ZHANG
;
Xudong TANG
Author Information
- Keywords: Traditional Chinese medicine; Spleen deficiency syndrome; Animal model; Evaluation index; Disease and syndrome combination model
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(3):652-658
- CountryChina
- Language:Chinese
- Abstract: The field of traditional Chinese medicine has a long history of applying modern science method in related research,and has made significant achievements in the field of disease and syndrome animal models.This paper reviewed the development history of the animal model of spleen deficiency syndrome,summarized and commented the modeling method,animal selection,evaluation index,digestive system disease and syndrome combination model.Small rodents,such as rats,are commonly used as representative animal models in research.Currently,the academic community mostly focuses on etiology and pathogenesis modeling,with limited use of chemical drugs and physical factors for modeling.The most common approach is the complex factor modeling method.Evaluation indicators include traditional Chinese medicine syndrome indicators,quantitative indicators related to"spleen"function and characteristics,as well as prescription counter-indicators.The focus of current research is the combination of disease patterns related to spleen deficiency,such as functional diarrhea/dyspepsia.The research on animal models of spleen.
