To Explore ICC Dysfunction Based on Spleen-Mitochondria Correlation
- VernacularTitle:基于脾-线粒体相关性探讨ICC功能障碍
- Author:
Yuchen WEI
1
,
2
;
Yiming WANG
;
Tai ZHANG
;
Jing KANG
;
Beihua ZHANG
;
Xudong TANG
Author Information
- Keywords: Correlation of spleen and mitochondria; Interstitial cells of Cajal; Symptoms overlap; Functional dyspepsia; Gastroesophageal reflux disease; Theory of Tong Jiang
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(3):646-651
- CountryChina
- Language:Chinese
- Abstract: The overlapping symptoms of functional gastrointestinal disorders(FGIDs)are complicated,which makes the diagnosis and treatment of FGIDs more difficult,at the same time aggravates the patients'psychological and economic burden and results in the consumption of medical resources.Functional dyspepsia(FD)and gastroesophageal reflux disease(GERD)may have a potential Pathophysiology relationship,which is mainly related to gastrointestinal motility disorders caused by lower esophageal sphincter relaxation and delayed gastric emptying.The spleen is the foundation of nurture,the source of Qi and blood biochemistry,disperses the fine in the whole body,contains the energy and the material which the organism needs.Mitochondria are known as"Power factories",producing heme as well as ATP from tricarboxylic acid cycle and oxidative phosphorylation to fuel life.The functions of spleen and mitochondria embody the same life activity in two different ways.It has been found that the dysfunction of interstitial cells of cajal(ICC)caused by energy metabolism disorder of mitochondria is closely related to gastrointestinal motility disorder.Therefore,based on the"Correlation between spleen and mitochondria",this paper discusses the relationship between ICC dysfunction and overlapping FD and GERD.It is suggested that the dysfunction of ICC caused by spleen deficiency and mitochondrial energy metabolism disorder is the important pathogenesis of overlapping FD and GERD.In addition,starting from the theory of Tong Jiang,it can provide higher clinical practical value for the diagnosis and treatment of overlapping FD and GERD.
