Optimization of Extraction Process for Yunpi Huatan Tongqiao Decoction
- VernacularTitle:运脾化痰通窍方提取工艺优化
- Author:
Jinfeng YU
1
;
Jing AI
;
Ning LUAN
;
Ming YAN
;
Zhenzhong WANG
;
Wei XIAO
;
Guifang YU
Author Information
- Keywords: Yunpi Huatan Tongqiao decoction; Extraction process; Box-Behnken response surface method; Fingerprint; Nalytic hierarchy process-independence weighting method; Quality control
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(3):591-600
- CountryChina
- Language:Chinese
- Abstract: Objective Establish the fingerprint of the group and optimize the extraction process of the Yunpi Huatan Tongqiao decoction.Methods The macroscopic characterization and similarity analysis of the extract fingerprint were carried out by applying the total statistical moment method.With baicalin,wogonin,rosmarinic acid,liquiritin,glycyrrhizic acid and paste yield as key quality attributes,and extraction time,water addition and extraction times as key process parameters,the optimal extraction process was selected by AHP-independent weight method,and the process was verified.Results Establishing a total statistical moment similarity evaluation method,and the average statistical moment similarity of the total amount of fingerprints of different extraction methods was 0.8807.The ANOVA results of the process evaluation model function are displayed that P<0.0001,R2=0.9904,indicating that the model was statistically significant.The best extraction process was determined as follows:adding 10-fold volume of water in the whole prescription,extracting for 1.5 h and extracting twice.Conclusion The total statistical moment analysis method that conforms to the fingerprint characteristics of the fingerprint of the extract was established,which was stable and reliable,which provided a reference basis for the quality control of the whole process of the subsequent process research.
