Basing on Glutamine Metabolism in the Treatment of Colorectal Cancer from"Yin Tumor"
10.11842/wst.20240107002
- VernacularTitle:基于谷氨酰胺代谢重编程从"阴瘤"论治结直肠癌
- Author:
Feiye WANG
1
;
Xinyu GUO
;
Yun XU
;
Lutian GONG
;
Li FU
;
Shanshan GU
;
Zhuo SONG
;
Yumei ZENG
;
Yufei YANG
Author Information
1. 中国中医科学院西苑医院 北京 100091
- Keywords:
Colorectal cancer;
Yin tumor;
Glutamine metabolism;
Tonifying
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2024;26(3):575-580
- CountryChina
- Language:Chinese
-
Abstract:
The theory of yin and yang is the modest differentiation thought of the traditional Chinese medicine under the guidance of overall dialectics,and the dynamic changes of yin and yang profit and loss can reflect the life activities of the human body.In the early literature research and clinical practice,the author's team found that the"yang deficiency and yin stagnation"is the key pathogen of colorectal cancer,the yang qi is insufficient,and the metabolites of the yin such as phlegm,wetness and stasis are lost in gasification and accumulate to form a"yin tumor",which is stagnant in the intestine and forms colorectal cancer.Yang Qi is the process of normal cell metabolism to produce energy,Yang Qi is insufficient,the"yin knot"of the thing in the body polymerizes into tumors,The imbalance of yin and yang can cause changes in energy or substance metabolism in the body,and glutamine is one of the amino acid which is the largest consumption of tumor cells,and its metabolic process not only provides a material basis for tumor cell growth,but also creates an acidic microenvironment of hypoxia to promote the proliferation and growth of tumor cells.This paper discusses the characteristics of glutamine metabolism of colorectal cancer cells in detail,aiming to explain the occurrence of colorectal cancer from the pathogenesis of"yang deficiency yin knot",and to explain the scientific theory of traditional Chinese medicine in the treatment of coloral cancer with the principle of Wenyang Tongxia,aiming to provide new ideas and methods for the comprehensive treatment of CRC.
