The effects of Src kinase inhibitor PP2 on learning and memory in rats with chronic alcohol exposure
10.16557/j.cnki.1000-7547.2024.03.012
- VernacularTitle:Src激酶抑制剂PP2对慢性酒精暴露大鼠学习记忆能力的影响
- Author:
Zhida LI
1
;
Yong ZHANG
Author Information
1. 鹤壁职业技术学院医学院医学影像技术教研室,鹤壁 458030
- Keywords:
chronic alcohol exposure;
learning and memory;
Src kinase inhibitor;
neuroinflammation;
rat
- From:
Chinese Journal of Neuroanatomy
2024;40(3):359-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of Src kinase inhibitor PP2 on learning and memory in rats with chronic alcohol(EtOH)exposure and its molecular mechanism.Methods:The chronic alcohol exposure model of rats was pre-pared by drinking method,and PP2 was given by intraperitoneal injection.The learning and memory ability of rats was detected by Morris water maze,the contents of IL-1β and TNF-α in hippocampus were detected by enzyme linked im-munosorbent assay(ELISA),and the expressions of Src,Iba-1 and iNOS in hippocampus were detected by Western Blot.Results:Chronic alcohol exposure could prolong the incubation period and escape time of rats.At the same time,the expression of Src,Iba-1 and iNOS,as well as the contents of IL-1β and TNF-α were increased in the hippocampus.PP2 can decrease the escape latency and the expression of Src,Iba-1,and iNOS in hippocampus of chronic alcohol exposed rats.In addition,the levels of IL-1β and TNF-α decreased.Conclusion:PP2 improves learning and memory impairment caused by chronic alcohol exposure by inhibiting nervous system inflammation.
