Associations of reproductive health indicators with lung function and COPD among female community residents aged 40 years and above in Songjiang District,Shanghai
10.3969/j.issn.1672-8467.2024.06.002
- VernacularTitle:上海市松江区40岁及以上社区女性居民生殖健康因素与肺功能及慢性阻塞性肺疾病的关联
- Author:
Xin YIN
1
;
Yi-Ling WU
;
Shan-Shan HOU
;
Jing LI
;
Wei LUO
;
Min-Jun YU
;
Jin-Xin ZANG
;
Wei WANG
;
Xu-Yan SU
;
Qi ZHAO
;
Yin-Feng ZHU
;
Gen-Ming ZHAO
;
Yong-Gen JIANG
;
Qing-Wu JIANG
;
Na WANG
Author Information
1. 复旦大学公共卫生学院流行病学教研室-公共卫生安全教育部重点实验室 上海 200032
- Keywords:
chronic obstructive pulmonary disease(COPD);
lung function;
reproductive health;
menopause;
pregnancy
- From:
Fudan University Journal of Medical Sciences
2024;51(6):882-889
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the associations of reproductive health indicators with lung function and chronic obstructive pulmonary disease(COPD)among women aged 40 years and above.Methods From Jul to Sep,2021,female subjects aged 40 years and above were randomly selected from the Shanghai Suburban Adult Cohort and Biobank for COPD screening.A questionnaire was used to obtain information on demographic characteristics and reproductive health indicators.Linear regression was used to analyze the effects of reproductive health indicators on forced vital capacity(FVC)and forced expiratory volume in the first second(FEV1).Logistic regression was also used to analyze the effects of reproductive health factors on FVC as a percentage of the predicted value(FVC%Pred)and FEV1%Pred as well as on COPD.Results A total of 1876 women aged 40 years and above were enrolled with mean age of(62.1±8.2)years old,among them,78.1%were menopausal,and 40.9%had been pregnant≥3 times.Multivariate analysis showed that FVC and FEV1 decreased in postmenopausal women,but menopause was not associated with a decrease in their percentage of predicted values.Pregnancies≥3 times was a risk factor for COPD(for 3 times,OR=4.92,95%CI:1.48-19.95,P<0.05;for≥4 times,OR=9.06,95%CI:2.32-41.57,P<0.01),while pregnancies of 2 times did not increase the risk of COPD.Conclusion In women aged 40 years and above,menopause is associated with poorer FVC and FEV1,and excessive pregnancy(≥3 times)is a risk factor for COPD.
