Core Needle Biopsy Is a More Conclusive Follow-up Method Than Repeat Fine Needle Aspiration for Thyroid Nodules with Initially Inconclusive Results: A Systematic Review and Meta-Analysis.
- Author:
Jung Soo PYO
1
;
Jin Hee SOHN
;
Guhyun KANG
Author Information
- Publication Type:Meta-Analysis ; Original Article
- Keywords: Thyroid nodule; Non-diagnostic or atypia of undetermined significance/follicular lesion; of undetermined significance; Follow-up core needle biopsy; Repeat fine-needle aspiration; Meta-analysis
- MeSH: Area Under Curve; Biopsy, Fine-Needle*; Biopsy, Large-Core Needle*; Diagnostic Tests, Routine; Follow-Up Studies*; Methods*; Odds Ratio; Prospective Studies; ROC Curve; Sensitivity and Specificity; Thyroid Gland*; Thyroid Nodule*
- From:Journal of Pathology and Translational Medicine 2016;50(3):217-224
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: This study investigated the appropriate management of thyroid nodules with prior non-diagnostic or atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) through a systematic review and meta-analysis. METHODS: This study included 4,235 thyroid nodules from 26 eligible studies. We investigated the conclusive rate of follow-up core needle biopsy (CNB) or repeat fine needle aspiration (rFNA) after initial fine needle aspiration (FNA) with non-diagnostic or AUS/FLUS results. A diagnostic test accuracy (DTA) review was performed to determine the diagnostic role of the follow-up CNB and to calculate the area under the curve (AUC) on the summary receiver operating characteristic (SROC) curve. RESULTS: The conclusive rates of follow-up CNB and rFNA after initial FNA were 0.879 (95% confidence interval [CI], 0.801 to 0.929) and 0.684 (95% CI, 0.627 to 0.736), respectively. In comparison of the odds ratios of CNB and rFNA, CNB had more frequent conclusive results than rFNA (odds ratio, 5.707; 95% CI, 2.530 to 12.875). Upon subgroup analysis, follow-up CNB showed a higher conclusive rate than rFNA in both initial non-diagnostic and AUS/FLUS subgroups. In DTA review of followup CNB, the pooled sensitivity and specificity were 0.94 (95% CI, 0.88 to 0.97) and 0.88 (95% CI, 0.84 to 0.91), respectively. The AUC for the SROC curve was 0.981, nearing 1. CONCLUSIONS: Our results show that CNB has a higher conclusive rate than rFNA when the initial FNA produced inconclusive results. Further prospective studies with more detailed criteria are necessary before follow-up CNB can be applied in daily practice.
