Research progress on anticancer mechanism of cantharidin and its derivatives
10.3969/j.issn.1672-8467.2024.04.023
- VernacularTitle:斑蝥素及其衍生物抗癌作用机制的研究进展
- Author:
Yan WANG
1
;
Ru-He JIANG
;
Yue YU
;
Yan DU
Author Information
1. 复旦大学附属妇产科医院研究所 上海 200090
- Keywords:
cantharidin;
cancer;
therapy;
mechanism;
signaling pathway
- From:
Fudan University Journal of Medical Sciences
2024;51(4):620-631
- CountryChina
- Language:Chinese
-
Abstract:
Cantharidin is a terpenoid compound secreted by Mylabrisphalerata Pallas.In a variety of cancer types,cantharidin has shown the effects of inhibiting cancer cell growth,proliferation and migration.The anticancer mechanism of cantharidin involves inducing cell cycle arrest and apoptosis,inhibiting autophagy,enhancing DNA damage,inhibiting DNA repair,and regulating various cell signaling pathways.This article reviews the mechanism and research progress of cantharidin and its derivatives in common cancer types,in order to identify novel targets of cancer treatment using cantharidin,and provide new direction for clinical research to improve anticancer therapy.
