Research progress on the role of leonurine in inflammation-related diseases
10.3969/j.issn.1672-8467.2024.04.022
- VernacularTitle:益母草碱在炎症相关性疾病中作用的研究进展
- Author:
Jia-Wei XIONG
1
;
Rui-Qi MA
;
Hua-Peng YU
;
Lin MOU
;
Xiao-Fen MO
Author Information
1. 复旦大学附属眼耳鼻喉科医院眼科,上海 200031
- Keywords:
leonurine;
inflammation;
nuclear transcription factor-κB(NF-κB);
phosphorylation;
cytokine
- From:
Fudan University Journal of Medical Sciences
2024;51(4):614-619
- CountryChina
- Language:Chinese
-
Abstract:
Leonurine(SCM-198)was discovered as one of the active constituents of the Herba Leonuri(HL).Now it can be artificially synthesized.Several recent researches has proven that it exhibits anti-inflammatory effect in several systems in animal models and cell culture in vitro.The key mechanism involves downgrading the activity of nuclear transcription factor-κB(NF-κB),thereby inhibiting the phosphorylation of several signal pathways such as PI3K/Akt,MAPK,ERK,and JNK,or upregulating the activity of Nrf2 related pathways,resulting in downregulated expression of inflammatory cytokines such as tumor necrosis factor-α(TNF-α),IL-1β,IL-2,IL-6,IL-8,inducible nitric oxide synthase(iNOS),cyclooxygenase-2(COX-2),chemokines,adhesion molecules,etc.Owing to the advantages of high safety and efficiency,the ease of administration,as well as its effectiveness in many organs and systems,leonurine has a widely prospect for future research and clinical applications.This article reviews the progress in the fundamental research of leonurine in multiple inflammation-related disease,and it could be expect to offer new possibilities for the treatment of these disease.
