The protective effect of COVID-19 vaccination on incidence of COVID-19 pneumonia and pulmonary function in early convalescence phase
10.3969/j.issn.1672-8467.2024.04.016
- VernacularTitle:新冠病毒疫苗接种对肺功能的保护作用及早期新冠肺炎的影响
- Author:
Nuo XU
1
;
Zhi-Wen SHEN
;
Yan-Ping YANG
;
Zhi-Hong CHEN
;
Li LI
Author Information
1. 复旦大学附属中山医院呼吸与危重医学科 上海 200032
- Keywords:
corona virus disease 2019(COVID-19);
vaccination inoculation;
pulmonary function
- From:
Fudan University Journal of Medical Sciences
2024;51(4):574-579,593
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of corona virus disease 2019(COVID-19)vaccination on incidence of COVID-19 pneumonia and pulmonary function in early convalescence phase.Methods A total of 1 178 COVID-19 patients from Zhongshan hospital,Fudan University were enrolled from 7 Jan 2023 to 7 Feb 2023 and divided into two groups according to the incidence of COVID-19 pneumonia.All the patients were asked to finish the questionnaire on COVID-19 related-symptoms,and other clinical parameters in our study.Vaccination situation,Pulmonary functions including ventilation,diffusion function and fractional exhaled nitricoxide(FeNO)were collected.T-tests and Chi-squared tests were used to analyze the protective effect of vaccination on pulmonary function and occurrence of COVID-19 pneumonia between groups.Univariate analysis and multivariate analysis were performed to predict the significant prognostic factors for incidence of COVID-19 pneumonia.Results Lung function including ventilation and diffusion function was significantly declined in unvaccinated patients than vaccinated patients(P<0.05).Those unvaccinated patients and patients with chronic diseases were more likely to have COVID-19 pneumonia and severe related symptoms.Vaccinated with two or three doses,rather than one dose of COVID-19 vaccines could protect the patients from COVID-19 pneumonia(P<0.05).Those with chronic diseases were inclined to have severe symptoms,while vaccination could alleviate the symptoms of those patients and patients with no history.Conclusion COVID-19 infection can impair the lung function of patients in early convalescence phase.COVID-19 vaccination could protect the patients from COVID-19 pneumonia,ameliorate the related symptoms and attenuate lung function decline.
