Expression of vascular inflammatory proteins in preeclamptic women and potential biomarkers for preeclampsia analysis
10.3969/j.issn.1672-8467.2024.04.012
- VernacularTitle:子痫前期孕妇血清中血管炎性蛋白的表达与潜在生物标志物分析
- Author:
Ting-Ting YANG
1
;
Xi-Xi CHENG
;
Hai-Yan LIU
;
Cheng-Jie WANG
;
Yao TANG
;
Wei-Rong GU
Author Information
1. 复旦大学附属妇产科医院产科 上海 200011
- Keywords:
preeclampsia;
serum;
biomarker;
vascular inflammatory proteins;
vascular cell adhesion molecule-1(VCAM-1)
- From:
Fudan University Journal of Medical Sciences
2024;51(4):543-551
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore potential predictive biomarkers for preeclampsia by analyzing the expression and characteristics of vascular-related inflammatory proteins in the serum of preeclamptic pregnant women.Methods A case-control study was conducted from Sep 2017 to Sep 2018 in the Obstetrics and Gynecology Hospital,Fudan University.Preeclamptic pregnant women and normotensive pregnant controls during the same period were recruited.The concentration of 12 vascular inflammation-related proteins in the patients'serum was determined by multiplex flow cytometry.The vascular-related inflammatory molecules were subjected to differential analysis by non-parametric t-test to obtain preeclampsia-related vascular inflammatory proteins.Finally,high-risk preeclampsia pregnancy serum samples from the biobank were retrieved.Serum concentrations of preeclampsia-related vascular inflammatory proteins were determined,and receiver operating characteristic(ROC)curve analysis was conducted for preliminary predictive assessment of preeclampsia.Results This study conducted a quantitative analysis of serum vascular inflammatory proteins in 39 cases of preeclampsia and 43 cases of control pregnant women,detecting 10 vascular inflammatory proteins expressed in maternal serum.Among these,myoglobin and vascular cell adhesion molecule-1(VCAM-1)exhibited significant elevation in the serum of preeclamptic pregnant women,while matrix metalloproteinase-9(MMP-9)showed a marked decrease.ROC curve analysis revealed that in 96 high-risk early pregnancy women,the area under the curve(AUC)for VCAM-1 reached 0.802,whereas myoglobin and MMP-9 did not significantly predict the occurrence of preeclampsia.Conclusion Preeclampsia patients exhibit abnormal expression of serum inflammatory proteins,among which VCAM-1 may be a potential biological marker for early pregnancy preeclampsia risk prediction.
