Traditional Chinese medicine"Shen Jiu Fang Modified"approach in treating glomerular cystic disease induced by FAT1 gene mutation:one case report
10.3969/j.issn.1672-8467.2024.03.018
- VernacularTitle:中药"肾九方加味"方案治疗FAT1基因突变引发的肾小球囊肿病:1例报告
- Author:
Hui-Jie LI
1
;
Di ZHANG
;
Yi-Fei ZHONG
;
Yue-Yi DENG
;
Wen-Shu GE
Author Information
1. 上海中医药大学附属龙华医院肾病科 上海 200032
- Keywords:
glomerulocystic kidney disease(GCKD);
Shen Jiu Fang;
FAT1;
gene mutation;
traditional Chinese medicine treatment
- From:
Fudan University Journal of Medical Sciences
2024;51(3):420-425,434
- CountryChina
- Language:Chinese
-
Abstract:
Glomerulocystic kidney disease(GCKD),a rare nephrocystic disorder,was the focus of this study.The FAT1 gene,comprising 27 exons,encoded a single-pass transmembrane protein with multiple biological functions.The extracellular portion of this protein consisted of 33 cadherin repeat sequences,5 epidermal growth factor-like domains,and a G-layer associated domain.This report detailed a case of glomerular cystic disease caused by a mutation in the FAT1 gene,which was treated with the traditional Chinese medicine formula'Shen Jiu Fang Modified'.This formula included Astragalus,Atractylodes,Poria,Angelica,Clematis,Silkworm,Hedyotis diffusa,Hibiscus leaf,among other ingredients,and aimed to invigorate the spleen and promote diuresis,as well as to nourish the kidneys and promote blood circulation.This case demonstrated the potential of traditional Chinese medicine in addressing rare kidney diseases,offering new insights for the diagnosis and treatment of similar complex cases.
