Clinical correlation between TNFRSF12A and hepatocellular carcinoma and its effect on immunoregulation of tumor cells
10.3969/j.issn.1672-8467.2024.03.011
- VernacularTitle:TNFRSF12A与肝癌的临床相关性及其与肿瘤免疫调控的相关研究
- Author:
Jie ZHU
1
;
Pei-Qi FANG
;
Bai-Shen PAN
;
Wei GUO
;
Bei-Li WANG
Author Information
1. 复旦大学附属中山医院检验科 上海 200032
- Keywords:
hepatocellular carcinoma;
TNFRSF12A;
stemness marker;
immune cell infiltration
- From:
Fudan University Journal of Medical Sciences
2024;51(3):368-377
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of the TNFRSF12A molecule in the pathogenesis of liver cancer.Methods Through comprehensive analysis of the Cancer Genome Atlas Program(TCGA)database and single-cell sequencing data,we studied the expression of TNFRSF12A in liver cancer and its correlation with prognosis.HPA database was utilized to analyze the subcellular localization of TNFRSF12A,and GO and KEGG analyses were performed by DAVID.TIME 2.0 was employed to analyze the correlation between TNFRSF12A and immune cell infiltration in liver cancer tissues.Results TNFRSF12A was found to be highly expressed in liver cancer tissues,significantly correlating with patient survival prognosis(OS:HR=1.61,P=0.007 0;RFS:HR=1.45,P=0.037 0;PFS:HR=1.30,P=0.099 0;DSS:HR=1.67,P=0.027 0),as well as age(P=0.046 7)and BCLC stage(P=0.045 6).TNFRSF12A co-expressed with tumor stem cell markers(CD24,SOX4,ANPEP),indicating a strong link to malignancy.Furthermore,molecular functional analysis unveiled that IL-2R primarily existed in the cell cytoplasm and played a role in processes such as cell apoptosis,invasion,and protein binding.Moreover,TNFRSF12A was associated with Treg cells and immune cell infiltration,further suggesting its role in tumor immune regulation.Conclusion TNFRSF12A exhibits a significant elevation within liver tumors and shows a notable correlation with patients'prognosis.Tumor cells engage in interactions with cytokines produced by Tregs,thereby reshaping the tumor microenvironment.The potential clinical significance of TNFRSF12A as a prognostic marker for tumors holds promise in offering novel avenues for personalized treatment and prognosis prediction.
