The relationship between TyG index in early pregnancy and the delivery of small for gestational age infant in patients with gestational diabetes mellitus
10.3969/j.issn.1672-8467.2024.03.009
- VernacularTitle:妊娠期糖尿病患者妊娠早期TyG指数与分娩小于胎龄儿的相关性
- Author:
Xilifu NUERBIYA
1
,
2
;
Zhang-Yan LI
;
Shu-Fei ZANG
;
Aisikaer GULISITAN
;
Rui ZHANG
;
Yue LI
;
Xin-Ming XU
;
Jun LIU
Author Information
1. 复旦大学附属上海市第五人民医院内分泌科 上海 200240
2. 喀什地区第二人民医院内分泌代谢科 喀什 844000
- Keywords:
gestational diabetes mellitus(GDM);
early pregnancy;
triglyceride-gluscose(TyG)index;
small for gestational age infant(SGA)
- From:
Fudan University Journal of Medical Sciences
2024;51(3):352-358,377
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between triglyceride-gluscose(TyG)index in early pregnancy and the delivery of small for gestational age infant(SGA)in patients with gestational diabetes mellitus(GDM).Methods A total of 1 532 pregnant women from Shanghai Fifth People's Hospital and the Second People's Hospital of Kashgar Region,who were enrolled in the study between Jan 2018 and Jun 2023 and met the inclusion criteria,were categorized into the group with GDM(754 cases)and the group without GDM(778 cases)based on the results of the oral glucose tolerance test(OGTT)conducted at 24-28 weeks of pregnancy.Within the GDM group,patients were further categorized into 3 groups based on neonatal weight:SGA group,large for gestational age infant(LGA)group,and appropriate for gestational age infant(AGA)group.A Logistic regression model was used to analyze the independent influences on SGA delivery in patients with GDM to analyze the correlation between the TyG index and the occurrence of SGA.The predictive value of the TyG index in early pregnancy for SGA delivery in GDM patients was analyzed using ROC curves.Results The TyG index in the SGA group of GDM patients was significantly lower than that in the LGA,AGA and control without GDM group(P＜0.05).Multifactorial logistic regression analysis revealed that the TyG index was independently correlated with the SGA in GDM patients(P＜0.05).The ROC curve analysis demonstrated a good predictive value of the TyG index in early gestation for SGA delivery in GDM patients(AUC=0.821,95%CI:0.763-0.879,P＜0.001).Conclusion The TyG index in early pregnancy among GDM patients is independently correlated with the occurrence of SGA infants and has a good predictive value for SGA delivery in GDM patients.
