Clinical practice of sepsis-induced immunosuppression: Current immunotherapy and future options
10.1016/j.cjtee.2023.11.001
- VernacularTitle:Clinical practice of sepsis-induced immunosuppression: Current immunotherapy and future options
- Author:
Fei PEI
1
;
Bin GU
;
Shu-Min MIAO
;
Xiang-Dong GUAN
;
Jian-Feng WU
Author Information
1. Department of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China
- Keywords:
Sepsis;
Sepsis-induced immunosuppression;
Immunotherapy;
Enrichment;
Classifier
- From:
Chinese Journal of Traumatology
2024;27(2):63-70
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a potentially fatal condition characterized by the failure of one or more organs due to a disordered host response to infection. The development of sepsis is closely linked to immune dysfunction. As a result, immunotherapy has gained traction as a promising approach to sepsis treatment, as it holds the potential to reverse immunosuppression and restore immune balance, thereby improving the prognosis of septic patients. However, due to the highly heterogeneous nature of sepsis, it is crucial to carefully select the appropriate patient population for immunotherapy. This review summarizes the current and evolved treatments for sepsis-induced immunosuppression to enhance clinicians' understanding and practical application of immunotherapy in the management of sepsis.
