Hypoxic preconditioning enhances hypoxic tolerance of hippocampal neurons and synaptic function of rat
10.3321/j.issn:0371-0874.2001.01.017
- VernacularTitle:低氧预适应增强大鼠海马神经元的耐缺氧能力
- Author:
Tong ZHAO
1
;
Shun YU
;
Ai-Shi DING
;
Fu-Zhuang WANG
;
Ming FAN
Author Information
1. Institute of Basic Medical Sciences
- From:
Acta Physiologica Sinica
2001;53(1):72-74
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxic preconditioning with different simulated altitudes (3?000 m and 5?000 m) was performed on Wistar rats and the evoked population spikes were recorded from the hippocampal slices of these rats. The results showed that the appearance of hypoxic injury potential (HIP) and the disappearance of presynaptic volley (PV) were significantly delayed in response to acute lethal hypoxia. HIP and PV delay became more apparent when the hypoxic preconditioning altitude was increased from 3?000 m to 5?000 m. After reoxygenation, the recovery rate of PV in hypoxic preconditioning groups at 3?000 m and 5?000 m was apparently higher than that of control. The above results suggest that hypoxic preconditioning of animals in vivo increases hypoxic tolerance of hippocampal neurons.
