ICAM-1 expression of rat brain microvascular endothelial cells caused by fluid shear force
10.3321/j.issn:0371-0874.2001.01.005
- VernacularTitle:流动剪切力对鼠脑微血管内皮细胞ICAM-1表达的影响
- Author:
Xiao-Yan SONG
1
;
Yan-Jun ZENG
;
Cai-Xia LI
;
Dong-Hua LIAO
;
Jin-Lin HU
;
Yan-Lei HAO
Author Information
1. Beijing Polytechnic University
- From:
Acta Physiologica Sinica
2001;53(1):13-17
- CountryChina
- Language:Chinese
-
Abstract:
We studied the effect of shear stress (SS) on intercellular adhesion molecule-1 (ICAM-1) expression of rat brain microvascular endothelial cells (RBMECs) using the parallel plate flow chamber method. It was demonstrated that RBMECs showed a time-dependent, but not a force-dependent, upregulation in ICAM-1 expression. Endothelial cell surface expression of ICAM-1 in the supernatants of RBMECs exposed to SS was not changed, thus excluding the possibility that the upregulated expression is due to the factors synthesized by these cells. These data throw light on understanding the signal transduction pathway inside the endothelial cells under the effect of SS.
