Effects of microinjection of adenosine into area postrema on heart rate, blood pressure and renal sympathetic nerve activity in rats
10.3321/j.issn:0371-0874.2000.04.011
- VernacularTitle:最后区注射腺苷对大鼠血压、心率和肾交感神经放电的影响
- Author:
Shuang CHEN
1
;
De-Pei LI
;
Rui-Rong HE
Author Information
1. 河北医科大学
- Keywords:
adenosine;
area postrema;
mean arterial pressure;
heart rate;
renal sympathetic nerve;
8-phenyltheophylline;
8-cyclopentyl-1,3-dipropylxanthine;
glibenclamide
- From:
Acta Physiologica Sinica
2000;52(4):313-317
- CountryChina
- Language:Chinese
-
Abstract:
The effects of microinjection of adenosine (Ado) into area postrema (AP) on mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve activity (RSNA) were examined in 53 anesthetized Sprague-Dawley rats. The results obtained are as follows. (1) Following microinjection of Ado (1 ng/60 nl) into AP, MAP, HR and RSNA were decreased from 13.76±0.46 kPa, 356.28±4.25 bpm and 100±0% to 11.23±0.49 kPa (P<0.001), 336.91±5.23 bpm (P<0.01) and 70.95±5.19% (P<0.001), respectively; (2) 8-phenyltheophylline (150 μg/kg, 0.2 ml,iv), a nonselective adenosine receptor antagonist, and 8-cyclopentyl-1,3-dipropylxanthine (500 μg/kg, 0.2 ml, iv), a selective A1 adenosine receptor antagonist, blocked the inhibitory effect of Ado completely; and (3) glibenclamide (5 mg/kg, 0.2 ml, iv), a blocker of ATP-sensitive potassium channel, also abolished the effect of Ado. The above results indicate that microinjection of Ado into AP induces inhibitory effects on MAP, HR and RSNA, which may be related to activation of ATP-sensitive potassium channels mediated by A1 receptors.
