DETECTION OF RELEASE OF ASPARTATE AND GLUTAMATE IN CAT SPINAL DORSAL HORN FOLLOWING NOXIOUS STIMULATION OF CUTANEOUS AND MUSCULAR AFFERENT FIBERS USING MICRODIALYSIS
10.3321/j.issn:0371-0874.1999.03.018
- VernacularTitle:微透析测试刺激皮肤和肌肉神经引起的天门冬氨酸和谷氨酸在脊髓的释放
- Author:
XUE-JUN SONG
1
;
YOU-SHENG SHU
;
PING-BO YIN
;
ZHI-QI ZHAO
Author Information
1. Chinese Academy of Sciences Shanghai Brain Research Institute
- Keywords:
glutamate;
aspartate;
microdialysis;
spinal nociception
- From:
Acta Physiologica Sinica
1999;51(3):343-346
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the possible mechanisms underlying the difference of NMDA and non-NMDA receptors in spinal nociception originating in skin and muscle, release of aspartate (Asp) and glutamate (Glu) in the spinal dorsal horn was detected by stimulation of cutaneous and muscular nerves in cats using microdialysis technique. Asp and Glu were increased respectively by (323±55)% and (169±16)% following stimulation of cutaneous nerve, but by (150±16)% and (218±42)% respectively following stimulation of muscular nerve. Asp increase was approximately three times higher than that of Glu following cutaneous nerve-stimulation (P<0.01), while Glu increase was approximately twice as high as that of Asp following muscular nerve-stimulation (P<0.05). It is likely that nociceptive cutaneous and muscular inputs preferentially elicite release of Asp and Glu respectively, resulting in a functional differentiation of NMDA and non-NMDA receptor in the mediation of different nociceptive information.
