ANTAGONISTIC EFFECT OF CCK-8 ON MORPHINE-INHIBITED ELECTRICAL AND CONTRACTILE ACTIVITIES OF RAT JEJUNUM IN VITRO
10.3321/j.issn:0371-0874.1998.04.018
- VernacularTitle:八肽胆囊收缩素对吗啡抑制大鼠离体空肠电与收缩活动的对抗作用
- Author:
Man-Ying XU
1
;
Dong-Xiao YANG
;
Shu-Zhen WANG
;
HONG-BO JIN
;
Xiang-Hui ZOU
;
Xin-Ping YANG
;
Ji-Sheng HAN
Author Information
1. 哈尔滨医科大学
- Keywords:
cholecystokinin octapeptide;
cholecystokinin receptor;
antagonist;
jejunum;
electrical activity;
contraction
- From:
Acta Physiologica Sinica
1998;50(4):469-473
- CountryChina
- Language:Chinese
-
Abstract:
In the present investigation, antagonistic action of cholecystokinin octapeptide (CCK-8)against morphine on the electrical and contractile activity of rat jejunum in vitro was studied. The results showed that the potentiation of acetylcholine (ACh) on both the burst of spike and the contractility were inhibited by morphine, which could be completely antagonized by CCK-8. The CCK-8 effect, again, could be suppressed by CCK-A receptor antagonist devazepide ( 10 nmol/L), but partially by CCK-B receptor antagonist L-365,260 at 10 nmol/L or completely at concentration of 30 nmol/L. The above results demonstrated that the antagonism of CCK-8 on morphine was mediated by both CCK-A and CCK-B receptors.
