A case report of atypical anti-glomerular basement membrane disease with membrane hyperplasia lesions

VernacularTitle:伴膜增生病变的非典型抗肾小球基底膜肾炎1例报道
Author: Xinping ZHANG ¹ ; Zichuang WANG ; Xiaoyong CHEN
Author Information

1. 河南中医药大学第二临床医学院肾病科,郑州 450003
Keywords: atypical anti-glomerular basement membrane nephritis; membrane proliferative lesion; nephrotic syndrome
From: Journal of Shanghai Jiaotong University(Medical Science) 2024;44(11):1472-1476
CountryChina
Language:Chinese
Abstract: Atypical anti-glomerular basement membrane(GBM)disease is rare,and the atypical anti-GBM disease with membrane hyperplasia lesion is even rarer.The treatment plan for it is not clear.This article reports a case of atypical anti-GBM disease with a negative anti-GBM antibody test,but renal tissue biopsy showed"glomerular membrane hyperplasia lesions with positive IgG linearity",which provides a reference for clinical diagnosis and treatment.The patient exhibited massive proteinuria,hematuria,edema,and renal impairment.After ruling out secondary factors,the patient was diagnosed with"atypical anti-GBM nephritis"by renal tissue biopsy,and was treated with glucocorticoids combined with cyclophosphamide,after which the patient developed a lung infection and acute left heart failure,and received regular hemodialysis treatment.Then the patient progressed to the stage of end-stage renal disease and continued to receive regular hemodialysis treatment.