Research progress in the relationship between FOXM1 and neoplasm metabolism

VernacularTitle:FOXM1与肿瘤代谢关系的研究进展
Author: Yu LI ^{1
,

2} ; Yifan JIANG ; Rongliang TONG ; Diyu CHEN ; Jian WU
Author Information

1. 浙江大学医学院附属第一医院肝胆胰外科,杭州 310003
2. 卫生部多器官联合移植研究重点实验室,杭州 310003
Keywords: forkhead box M1(FOXM1); tumor; metabolism; inhibitor; tumor microenvironment
From: Journal of Shanghai Jiaotong University(Medical Science) 2024;44(10):1323-1329
CountryChina
Language:Chinese
Abstract: FOXM1(forkhead box M1)is an important member of the FOX transcription factor family and plays a critical role in driving the progression of multiple malignancies through its transcriptional regulatory functions.Moreover,the overexpression of FOXM1 is associated with poor prognosis in many types of cancer,as it regulates a variety of biological processes such as gene expression,cell proliferation,invasion,metastasis,and apoptosis.Presently,aberrant metabolic reprogramming has been considered as the major characteristic of cancer development,determining the survival,growth,and proliferation of tumor cells.Accumulating evidence suggests that FOXM1 serves as a"bridge"between metabolism and tumorigenesis.This review aims to provide a comprehensive summary of the research progress in the relationship between FOXM1 and tumor cell metabolism,offering theoretical insights for the development of novel anti-cancer drugs targeting FOXM1.