Impact of folic acid and active folate supplementation on red blood cell folate levels in patients with unexplained recurrent pregnancy loss and MTHFR 677TT genotype
10.3969/j.issn.1674-8115.2024.06.009
- VernacularTitle:普通叶酸与活性叶酸补充对于MTHFR 677TT型不明原因反复流产患者红细胞叶酸水平的影响
- Author:
Yongjie LU
1
;
Shuchen HOU
;
Liang CHANG
;
Ping LIU
Author Information
1. 北京大学第三医院妇产科,生殖医学中心,女性生育力促进全国重点实验室,国家妇产疾病临床医学研究中心(北京大学第三医院),辅助生殖教育部重点实验室(北京大学),北京市生殖内分泌与辅助生殖技术重点实验室(北京大学第三医院),北京 100191
- Keywords:
methylenetetrahydrofolate reductase(MTHFR);
unexplained recurrent pregnancy loss(UPRL);
5-methyltetrahydrofolate(5-MTHF)
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2024;44(6):741-745
- CountryChina
- Language:Chinese
-
Abstract:
Objective·To study the effects of folic acid and active folate supplementation on red blood cell folate levels in patients with unexplained recurrent pregnancy loss(URPL)and methylenetetrahydrofolate reductase(MTHFR)677TT genotype.Methods·A total of 45 patients with MTHFR 677TT genotype and URPL in the Center for Reproductive Medicine of Peking University Third Hospital from January to December 2021 were selected.They were divided into three groups according to folic acid supplementation,including 16 cases in Group A(who had not received any form of folic acid supplementation before the study began,but received active folic acid supplementation after the study began),15 cases in Group B(who had received ordinary folic acid supplementation before the study began,and active folic acid supplementation after the study began),and 14 cases in Group C(ordinary folic acid was supplemented before the start of the study,and after the start of the study,ordinary folic acid and active folic acid were supplemented together).The concentration of 5-methyltetrahydrofolate(5-MTHF)in red blood cells was measured and compared at the time of enrollment(first measurement)and after supplementation(second measurement).Results·There was no statistically significant difference in the first measurement of 5-MTHF concentrations in red blood cells between any two groups of patients in the three groups.Compared with the first measurement of 5-MTHF concentrations in red blood cells,the second increased(all P=0.000);the increase in 5-MTHF concentrations in red blood cells in Group B was higher than that in Group A(all P=0.000);the increasing 5-MTHF concentration in Group B was higher than that in Group A(1=2.373,P=0.049),but there was no significant difference between Group B and Group C.Conclusion·Compared with folic acid supplementation,active folate supplementation can better improve red blood cell folate levels in patients with MTHFR 677TT genotype and URPL in a short period.
