Functions of SNARE complex in glial cells and its relationship with the development of depressive disorder

VernacularTitle:胶质细胞内SNARE复合体功能及其与抑郁障碍发生的关系
Author: Juanhua GU ¹ ; Yang JIAO ; Lin LU ; Linlin WANG
Author Information

1. 昆明医科大学生物医学工程研究院,昆明 650500
Keywords: depression; soluble N-ethylmaleimide-sensitive factor attachment protein receptor(SNARE)complex; glia cells
From: Journal of Shanghai Jiaotong University(Medical Science) 2024;44(5):653-657
CountryChina
Language:Chinese
Abstract: Depression is a common cause of human disability and death.Some patients are not sensitive to antidepressants,and also the recurrence rate is very high.Unfortunately,there are many problems with existing antidepressants.So,it is urgent to find a new antidepressant aiming at multiple targets.Recently,researchers have found that soluble N-ethylmaleimide-sensitive factor attachment protein receptor(SNARE)complex is closely related to the progression of depression.This review discusses the potential mechanisms of the SNARE complex in glial cells,and hopes to contribute to the understanding of depression and provide new ideas for clinical development of novel antidepressant drugs.