Application of cell blocks to assist in precise cytological diagnosis of serous effusion
10.3760/cma.j.cn112151-20240120-00054
- VernacularTitle:应用细胞蜡块辅助浆膜腔积液细胞学精准诊断
- Author:
Mingjun SUN
1
;
Longteng LIU
;
Chenyang LI
;
Dongge LIU
;
Lan CHEN
Author Information
1. 北京医院病理科 国家老年医学中心 中国医学科学院老年医学研究院，北京 100730
- Keywords:
Specimen handling;
Pleural effusion;
Cytological techniques;
Immunohistochemistry;
Serous effusion
- From:
Chinese Journal of Pathology
2024;53(8):830-836
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the importance of cell block and immunohistochemistry in the accurate diagnosis of serous effusion.Methods:A retrospective study was conducted on 3 124 cases of serous effusion from the Department of Pathology, Beijing Hospital from 2018 to 2022, include 2 213 cases of pleural effusion, 768 cases of peritoneal effusion, 143 cases of pericardial effusion. There were 1 699 males (54.4%) and 1 425 females (45.6%), average age 69 years old. Of which 1 292 cases were prepared with cell blocks and examined with immunohistochemical stain.Results:The percentage of malignant diagnosis increased from 64.9% (839/1 292) to 84.0% (1 086/1 292) after cell block preparation, and 1 086 cases were accurately diagnosed with histological type and/or origin of primary tumor. The undetermined diagnosis of suspected malignancy decreased from 13.3% (172/1 292) to 0.1% (1/1 292) and that of atypical hyperplasia from 18.8% (243/1 292) to 0.4% (5/1 292). The negative result for malignancy rate increased from 3.0% (38/1 292) to 15.5% (200/1 292). The differences highlighted above were statistically significant (Pearson′s chi-squared test=12.739, P<0.01). Conclusion:Application of immunohistochemistry based on cell block can significantly improve malignant diagnosis in serous effusion, identify tumor origin and histological type as well as decrease the uncertain diagnosis.
