Prognostic value of Doppler ultrasound combined with Cyfra21-1 and sIL-2R in cervical lymph node metastasis of thyroid micropapillary carcinoma
10.3760/cma.j.cn115807-20240205-00038
- VernacularTitle:多普勒超声联合Cyfra21-1、sIL-2R对甲状腺微小乳头状癌颈侧区淋巴结转移的预测价值
- Author:
Jin TANG
1
;
Runqin MIAO
;
Li YANG
;
Yanchao QIN
;
Zhaojie WANG
;
Bo ZHANG
Author Information
1. 山西省肿瘤医院 中国医学科学院肿瘤医院山西医院 山西医科大学附属肿瘤医院超声科，太原市 030001
- Keywords:
Thyroid carcinoma;
Papillary thyroid microcarcinoma;
Cervical lymph node metastasis;
Doppler ultrasound;
Cytokeratin fragment 19;
Soluble interleukin-2 rec
- From:
Chinese Journal of Endocrine Surgery
2024;18(5):691-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of Doppler ultrasonography combined with cytokeratin fragment 19 (Cyfra21-1) and soluble interleukin-2 receptor (sIL-2R) in cervical lymph node metastasis of thyroid micropapillary carcinoma.Methods:102 patients with minimal papillary carcinoma of thyroid confirmed by surgery and pathology admitted to Ultrasound Department, Shanxi Cancer Hospital from Aug. 2020 to Aug. 2023 were selected and treated with thyroidectomy plus central region and at least one cervical lymph node dissection. Among them, There were 24 cases in the LLNM group and 78 cases in the non-LLNM group.Results:There were significant differences in age, shape, nodular and capsule contact area, tumor shape aspect ratio > 1, blood flow, microcalcification, serum Cyfra21-1 and serum sIL-2R levels between the two groups (Cyfra21-1: P<0.001, sIL-2R: P=0.001). Logistic regression analysis showed that age ≥50 years old ( OR=0.443, 95% CI: 0.217-0.904), microcalcification ( OR=2.787, 95% CI: 1.491-5.208), Cyfra21-1>3.3ng/ml ( OR=3.117, 95% CI: 1.404-6.922) and sIL-2R > 110.45pmol/L ( OR=3.408, 95% CI: 1.473-7.884) were independent risk factors for cervical lymph node metastasis in PTMC patients ( P < 0.05). The ROC curve results showed that the area under the curve of cervical lymph node metastasis predicted by Doppler ultrasound combined with Cyfra21-1 and sIL-2R was 0.82, and the sensitivity and specificity were 83.67% and 70.56%, respectively. Conclusions:The calcification features of Doppler ultrasound and the elevation of serum Cyfra21-1 and sIL-2R are closely related to cervical lymph node metastasis of thyroid micropapillary carcinoma. The combination of Doppler ultrasound with serum Cyfra21-1 and sIL-2R has important reference value in predicting cervical lymph node metastasis.
