Prognostic value of virtual touch tissue imaging quantitative combined with serum TK1 detection for tumor recurrence after breast preserving surgery for triple-negative breast cancer
10.3760/cma.j.cn115807-20240710-00237
- VernacularTitle:声触诊组织成像定量技术联合血清胸苷激酶1检测对三阴性乳腺癌保乳术后肿瘤复发的预测价值
- Author:
Bo TANG
1
;
Yanni XIANG
;
Sanmei YU
;
Lingyao PENG
Author Information
1. 台州市第一人民医院超声科，台州 318020
- Keywords:
Triple negative breast cancer;
Breast-preserving surgery;
Virtual touch tissue imaging quantitative;
Recurrence;
Thymidine kinase 1
- From:
Chinese Journal of Endocrine Surgery
2024;18(5):661-664
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of virtual touch tissue imaging quantitative (VTIQ) combined with serum thymidine kinase 1 (TK1) detection in predicting the recurrence of triple negative breast cancer (TNBC) after breast preservation surgery.Methods:A total of 102 TNBC patients admitted to our hospital from May. 2020 to Apr. 2022 who underwent elective breast-preserving surgery were selected as the study objects. VTIQ was examined after surgery, shear wave velocity (SWV) was measured, and serum TK1 was detected. All patients were followed up after surgery, and tumor recurrence two years after surgery was statistically analyzed. Multivariate Logistic regression analysis was used to explore the influencing factors of tumor recurrence after TNBC breast-preserving preservation, and ROC curve was drawn to analyze the predictive value of SWV and serum TK1 levels on tumor recurrence.Results:The tumor recurrence rate of 102 TNBC patients was 29.41% (30/102) at 2 years after breast-preserving surgery. The TNM stage, lymph node metastasis, the levels of SWV and TK1 in the relapsed group were higher ( χ2=4.42, χ2=6.41, t=6.97, t=6.15, all P<0.05). Multivariate Logistic regression analysis showed that lymph node metastasis, SWV and serum TK1 level were influential factors for tumor recurrence at 2 years after breast-preserving surgery in TNBC patients ( OR=3.093, OR=3.501, OR=2.939, all P<0.05). ROC curve analysis showed that the AUC values of SWV and serum TK1 levels and their combined detection in predicting tumor recurrence after breast-preserving in TNBC patients were 0.821, 0.778 and 0.869, respectively, the sensitivity was 66.67%, 73.33% and 83.33%, respectively, and the specificity was 81.94%, 76.39% and 79.17%, respectively. The combined detection of SWV and serum TK1 level was more effective than the single detection in predicting tumor recurrence in patients with TNBC after breast-preserving surgery. Conclusion:SWV and serum TK1 levels are related to tumor recurrence after TNBC, and can predict tumor recurrence, and the combined detection of the two indicators can improve the prediction efficiency of tumor recurrence after TNBC.
