Effects of ultrasound-guided serratus plane block on stress response, serum CA153 and NSE levels in patients undergoing radical mastectomy
10.3760/cma.j.cn115807-20240507-00153
- VernacularTitle:超声引导下前锯肌平面阻滞对乳腺癌根治术患者应激反应及血清CA153、NSE水平的影响
- Author:
Jie HUANG
1
;
Zhipeng CHEN
;
Kun HUANG
;
Qing GUO
;
Kebing HUANG
Author Information
1. 汉中市中心医院麻醉科，汉中 723000
- Keywords:
Breast cancer;
Radical mastectomy;
Ultrasound-guided serratus plane block;
Cancer antigen 153;
Neuron-specific enolase;
Stress
- From:
Chinese Journal of Endocrine Surgery
2024;18(5):656-660
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of ultrasound-guided serratus plane block (US-SPB) on stress response, serum cancer antigen 153 (CA153) and neuron-specific enolase (NSE) levels in patients undergoing radical mastectomy.Methods:A total of 110 patients with radical mastectomy who were admitted to our hospital from Feb. 2022 to Feb. 2024 were chosen and separated into US-SPB group ( n=55, US-SPB) and control group ( n=55, conventional anesthesia) by the principle of random number table. The differences of stress index, tumor index, pain, sedation, and operation related index were observed between the two groups. Results:24h after operation, serum cortisol (Cor), epinephrine (EPI) and noradrenaline (NE) in US-SPB group were significantly lower than those in control group ( t=4.69, 5.07, 5.38, P<0.05) ; The levels of serum CA153 and NSE in US-SPB group were significantly lower ( t=2.15, 2.04, P<0.05) ; The visual analogue scales (VAS) scores and Ramsay sedation score (RSS) scores in US-SPB group were significantly lower at 6h, 12h and 24h after surgery (VAS: Finter-group =17.67, Pinter-group <0.05; Ftime =15.58, Ptime <0.05; Finteraction =0.96, Pinteraction > 0.05; RSS: Finter-group =12.77, Pinter-group <0.05; Ftime =10.88, Ptime <0.05; Finteraction =0.32, Pinteraction > 0.05) ; The intraoperative dosage of remifentanil and the postoperative dosage of sufentanil in US-SPB group were significantly lower ( t=1.99, P<0.05) . Conclusion:US-SPB can not only reduce the stress response of patients undergoing radical mastectomy, but also have a positive effect on the reduction of tumor marker levels, and the pain management effect is better.
