Correlation among CDK4, BCRP expression and pathological features, prognosis of breast cancer
10.3760/cma.j.cn115807-20240109-00009
- VernacularTitle:细胞周期蛋白依赖性激酶4及乳腺癌耐药蛋白表达与乳腺癌病理特征及预后的相关性研究
- Author:
Zhenzhu QIN
1
;
Xiangzhen PAN
;
Deba SONG
;
Yajuan ZHANG
Author Information
1. 商丘市第一人民医院病理科，商丘 476100
- Keywords:
Breast cancer;
Cyclin-dependent kinase 4;
Breast cancer resistance protein
- From:
Chinese Journal of Endocrine Surgery
2024;18(5):638-642
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation of cyclin-dependent kinase 4 (CDK4) and breast cancer resistance protein (BCRP) expression with pathological features and prognosis of breast cancer.Methods:From Jan. 2020 to Jun. 2021, 132 breast cancer patients admitted to our hospital were chosen. The surgically removed breast cancer tissues and adjacent tissues of all patients were collected, and the expressions of CDK4 and BCRP were detected by immunohistochemical staining. Clinical data of all patients were collected, and the correlation among CDK4, BCRP expression and pathological features, prognosis was analyzed.Results:The positive expression rates of CDK4 and BCRP in breast cancer tissues were higher than those in adjacent tissues ( P <0.05) ; The positive expression rate of CDK4 and BCRP was associated with differentiation degree, TNM stage and lymph node metastasis (all P <0.05) ; Kaplan-Meier analysis showed that the cumulative survival rate of CDK4 and BCRP negative expression group was higher than that of positive expression group ( P <0.05) ; Differentiation degree, TNM stage, lymph node metastasis, CDK4 expression and BCRP expression were independent prognostic factors for overall survival of breast cancer patients (all P <0.05) . Conclusions:CDK4 and BCRP have high positive expression rates in breast cancer tissues, and their expression is related to pathological features, with certain value in evaluating the prognosis of breast cancer patients.
