Research progress of non-histone crotonylation modification in cell biology functions
10.3760/cma.j.cn115807-20230109-00007
- VernacularTitle:非组蛋白巴豆酰化修饰在细胞生物学功能中的研究进展
- Author:
Zhaokun LI
1
;
Nan LIANG
;
Hui SUN
Author Information
1. 吉林大学中日联谊医院甲状腺外科，吉林省外科转化医学重点实验室，吉林省甲状腺疾病防治工程实验室，长春 130000
- Keywords:
Crotonylation;
Non-histone;
Cell biology functions
- From:
Chinese Journal of Endocrine Surgery
2024;18(4):583-585
- CountryChina
- Language:Chinese
-
Abstract:
Crotonylation is a protein post-translational acylation modification, although mainly focused on histones, but more and more studies have found that non-histone crotonylation modifications can participate in important biological functions of the human body. By investigating the relevant literature in recent years, this paper systematically elaborates the content of non-histone crotonylation modification. Firstly, the regulatory mechanism of crotonylation, that is, the transfer of crotonyl groups on protein lysine regulated by multiple enzyme systems, was elucidated. Secondly, it is described that non-histone proteins with crotonylation can participate in biological processes such as DNA damage response, cell proliferation, myogenic differentiation, and tissue fibrosis. This article aims to provide a theoretical basis for subsequent non-histone crotonylation research by reviewing the regulation and disease aspects of non-histone crotonylation modification in recent years, and to explore new methods for the clinical prevention and treatment of related diseases.
