Colorectal cancer with β-catenin protein expression deficiency: a clinicopathological analysis
10.3760/cma.j.cn112151-20230721-00019
- VernacularTitle:β连环素表达缺失结直肠癌的临床病理学分析
- Author:
Yangyang ZHANG
1
;
Xuan XIN
;
Liquan BI
;
Fuyun SHI
;
Ruixue CAO
;
Yanmei WANG
;
Xiaohong LIU
Author Information
1. 解放军第九六〇医院病理科，济南 250031
- Keywords:
Colorectal neoplasms;
beta Catenin;
DNA mutational analysis;
Immunohistochemistry
- From:
Chinese Journal of Pathology
2024;53(3):288-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological features and molecular characteristics of β-catenin-deficient colorectal cancer.Methods:The clinical, pathological and molecular features of 11 colorectal cancers with β-catenin protein loss diagnosed at the 960th Hospital of People′s Liberation Army of China, from January 2012 to November 2022 were analyzed.Results:Among the 11 patients, 3 were males and 8 were females. Their age ranged from 43 to 74 years, with the median age of 59 years. Six were in the left colon and 5 were in the right colon. One of the 11 cases had lymph node metastasis, 10 cases were well and moderately differentiated adenocarcinoma, and 1 was mucinous adenocarcinoma. Eight cases were of TNM stage T4, 2 of T1 stage and 1 of Tis stage. β-catenin protein was not detected using immunohistochemistry. Sanger sequencing revealed the presence of fragment-deletion mutation in exon 3 of CTNNB1 gene, resulting in loss of β-catenin protein expression.Conclusion:β-catenin deficiency is present in a small number of colorectal cancers and may be associated with exon 3 mutations of CTNNB1 gene.
