Changes and clinical significance of VEGF and VCAM-1 levels in peripheral blood of patients undergoing breast cancer resection before and after radiotherapy
10.3760/cma.j.cn115807-20240615-00205
- VernacularTitle:乳腺癌手术切除患者放疗前后外周血VEGF、VCAM-1水平变化及临床意义
- Author:
Dongyu HU
1
;
Hui LI
;
Haiying LIU
;
Dong YANG
Author Information
1. 济宁医学院附属医院肿瘤科，济宁 272113
- Keywords:
Breast cancer;
Surgery;
Radiotherapy;
Vascular endothelial growth factor;
Vascular cell adhesion molecule-1
- From:
Chinese Journal of Endocrine Surgery
2024;18(4):559-563
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes and clinical significance of vascular endothelial growth factor (VEGF) and vascular cell adhesion molecule-1 (VCAM-1) levels in patients undergoing breast cancer resection before and after radiotherapy.Methods:A total of 110 patients who were treated in our hospital from Jun. 2022 to Jun. 2023 for breast cancer and were to receive radiotherapy after surgery were prospectively selected as the observation group. Another 110 healthy volunteers were selected as the control group. The levels of VEGF and VCAM-1 in peripheral blood were compared, and the relationship among general data, tumor pathology and peripheral blood VEGF and VCAM-1 in the observation group was analyzed, and their relationship with disease and prognosis was analyzed.Results:VEGF and VCAM-1 levels in peripheral blood in the observation group were significantly higher ( F=1288.37, 309.32, P<0.05). The levels of VEGF and VCAM-1 in peripheral blood in the observation group were significantly lower than before radiotherapy ( t=23.45, 11.88, P<0.05). Before and after radiotherapy, VEGF and VCAM-1 levels in peripheral blood in the observation group were correlated with tumor stage, tumor differentiation degree and Ki-67 proliferation index ( ttumor stage=7.05, 2.14, 4.52, 4.76, ttumor differentiation degree=7.12, 6.62, 2.81, 3.15, tKi67 proliferation index=7.25, 4.60, 4.24, 2.48, P<0.05) ; Of 110 patients in the observation group, 73 were effective and 34 were ineffective. VEGF and VCAM-1 in effective group were significantly lower ( t=7.27, 9.08, P<0.05). Spearman correlation coefficient analysis showed that VEGF and VCAM-1 levels were significantly positively correlated with tumor stage and Ki67 proliferation index before and after radiotherapy ( rbefore radiotherapy=0.64, 0.54, 0.52, 0.52, rafter radiotherapy=0.32, 0.39, 0.37, 0.24, P<0.05), and negatively correlated with tumor differentiation degree ( rbefore radiotherapy=-0.41, -0.31, rafter radiotherapy=-0.68, -0.41, P<0.05). The prognostic value of combined radiotherapy was 0.801 [95% CI (0.714-0.871) ], which was higher than that of VEGF and VCAM-1 alone 0.690 [95% CI (0.5955-0.775) ] and 0.734 [95% CI (0.641-0.814) ]. Conclusion:The changes of VEGF and VCAM-1 levels in peripheral blood have a certain value in evaluating the short-term prognosis of patients undergoing breast cancer resection by radiotherapy.
