The relationship between serum BHMT level and visceral fat area in patients with type 2 diabetes mellitus and its predictive value for diabetic nephropathy
10.3760/cma.j.cn115807-20230802-00037
- VernacularTitle:血清BHMT水平与2型糖尿病患者内脏脂肪面积的关系及其对糖尿病肾病的预测价值
- Author:
Ping HU
1
;
Yan DAI
;
Fuyuan LI
;
Mingqin GE
Author Information
1. 临沂市中心医院内分泌科，临沂 276400
- Keywords:
Type 2 diabetes;
Diabetic nephropathy;
Betaine homocysteine methyltransferase;
Visceral fat area
- From:
Chinese Journal of Endocrine Surgery
2024;18(4):554-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between serum betaine homocysteine methyltransferase (BHMT) level and visceral fat area (VAF) in patients with type 2 diabetes mellitus (T2DM) and its predictive value for diabetic nephropathy (DN) .Methods:A retrospective study was conducted to select 170 patients with T2DM admitted to the hospital from Apr. 2021 to Apr. 2023 as the study subjects. According to the occurrence of DN, the patients were divided into two groups: DN group and non-DN group. All patients were tested for serum BHMT and VAF, and the relationship between them was analyzed by bivariate correlation. The baseline data of patients were collected, and the correlation between serum BHMT and VAF levels and DN in patients with T2DM was analyzed by binary Logistic regression. Receiver operating characteristic curve (ROC) was used to analyze the predictive value of serum BHMT and VAF levels for DN in patients with T2DM.Results:DN occurred in 34 of 170 patients with T2DM, with an incidence of 20.00%. The proportion of patients with DN combined with hypertension [61.76% (21/34) ] was higher than that of non-DN group [41.91% (57/136) ]. The levels of glycosylated hemoglobin (HbA1c), homocysteine (Hcy) and VAF were (8.97±1.53) %, (15.87± 5.09) μmol/L, (113.62±18.74) cm 2 respectively, higher than those in non-DN group [ (8.16± 1.27) %, (11.65±4.81) μmol/L, (92.61±14.17) cm 2]. The level of BHMT was (57.74± 9.18) pg/ml, lower than that in non-DN group [ (78.74±11.53) pg/ml] ( P<0.05). The levels of serum creatinine (Scr), blood urea nitrogen (BUN) and urinary albumin excretion rates (UAER) in DN group were (71.74±9.81) μmol/L, (8.18±1.27) mmol/L, (106.61±28.61) mg/24 h respectively, higher than those in non-DN group [ (57.11±10.06) μmol/L, (5.29±1.02) mmol/L, (14.65± 2.52) mg/24 h] ( P<0.05). BHMT was negatively correlated with VAF, Scr, BUN and UAER ( r<0, P<0.05). Binary Logistic regression analysis showed that high levels of HbA1c, Hcy and VAF were risk factors for DN in patients with T2DM ( OR>1, P<0.05). High level of BHMT was a protective factor for DN in patients withT2DM ( OR<1, P<0.05). The results of ROC curve showed that the AUC of BHMT, VAF levels and combined prediction of DN in patients with T2DM were all>0.70, which had certain predictive value, and the combined detection had the highest. Conclusion:Serum BHMT level is negatively correlated with VAF in patients with T2DM, and serum BHMT and VAF levels are closely related to the occurrence of DN in patients with T2DM, both of which can effectively predict the risk of DN in patients.
