Florid vascular proliferation of the intestinal tract: a clinicopathological analysis of ten cases
10.3760/cma.j.cn112151-20220608-00511
- VernacularTitle:肠道旺炽性血管增生10例临床病理学分析
- Author:
Chuanni FENG
1
;
Mengyuan SHAO
;
Tangchen YIN
;
Meng SUN
;
Lu ZHAO
;
Jiahan LIU
;
Weng I LAO
;
Lin YU
;
Jian WANG
Author Information
1. 复旦大学附属肿瘤医院病理科 复旦大学上海医学院肿瘤学系 复旦大学病理研究所，上海 200032
- Keywords:
Intestinal diseases;
Intussusception;
Vascular neoplasms;
Diagnosis, differential;
Florid vascular proliferation
- From:
Chinese Journal of Pathology
2023;52(3):262-267
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological features, pathologic diagnosis and differential diagnosis of florid vascular proliferation (FVP) of the intestinal tract.Methods:Ten cases of FVP of the intestinal tract diagnosed from 2010 to 2020 at Fudan University Shanghai Cancer Center were collected. The histomorphology and immunohistochemical staining were evaluated and the relevant literature was reviewed.Results:There were five males and five females, aging from 28 to 76 years (mean 51.0 years; median 50.5 years). Five cases occurred in the colon, three cases in the small intestine, and one each case in the inguinal region and cecum. Clinically, the patients mainly presented with abdominal pain, diarrhea and hematochezia. Seven of nine patients with imaging data showed associated intussusception. Microscopically, the lesion presented lobular growth of florid proliferation of small vessels extending through the bowel wall. The vascular channels were lined with bland endothelial cells with no nuclear atypia and infrequent mitoses. The overlying mucosa showed chronic ulceration. Immunohistochemically, endothelial cells of FVP were positive for CD31, CD34, ERG and Fli1, the stromal spindle cells expressed SMA, and the Ki-67 proliferation index was low (5%-30%). None of 4 patients with follow-up information had local recurrence.Conclusions:FVP is a rare benign vascular proliferation lesion which often occurs in the intestinal tract and is associated with intussusception. Accurate pathologic diagnosis of FVP requires close combination of radiological examinations. FVP is easily misdiagnosed as a true vascular tumor, especially angiosarcoma. It is necessary to better understand FVP to avoid misdiagnosis.
