Association between 25 (OH) D3 and vascular complications in type 2 diabetes mellitus at different BMI levels
10.3760/cma.j.cn115807-20240201-00034
- VernacularTitle:不同BMI水平T2DM患者25（OH）D3与糖尿病血管并发症的关联分析
- Author:
Wei HAN
1
;
Yanjun YANG
;
Yanyuan ZUO
Author Information
1. 池州市人民医院内分泌科，池州 247000
- Keywords:
Type 2 diabetes;
Body mass index;
25-hydroxyvitamin D3;
Vascular complications of diabetes
- From:
Chinese Journal of Endocrine Surgery
2024;18(3):352-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relativity between 25-hydroxyvitamin D3 (25 (OH) D3) and vascular complications in type 2 diabetes mellitus (T2DM) patients at different body mass index (BMI) levels.Methods:A total of 113 T2DM patients admitted to Chizhou People’s Hospital from Oct. 2021 to Oct. 2023 were selected as the study objects. The enrolled patients were divided into normal group, overweight group and obese group according to BMI level. General data (gender, age, course of disease, smoking history, drinking history, family history of hypertension and diabetes) and laboratory indicators were collected, including triglyceride (TG), creatinine (Cr), high-density lipoprotein-cholesterol (HDL-C), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), urinary albumin/creatinine ratio (UACR), albumin (Alb), blood calcium, blood phosphorus, 25 (OH) D3, etc. Spearman correlation analysis was used to analyze the correlation between diabetic vascular complications and 25 (OH) D3, and Logistic regression was used to analyze the risk factors of diabetic vascular complications among different BMI groups.Results:The disease course of overweight and obesity group was (8.51±2.39) years, (10.82±3.02) years, TG was (2.58±0.45) mmol/L, (3.24±0.64) mmol/L, TC was (6.23±1.45) mmol/L, (9.32±2.01) mmol/L, and BMI was (26.48±1.53) kg/m 2, (30.12±1.62) kg/m 2, higher than those of the control group ( P<0.05). The level of LDL-C (3.58±1.02) mmol/L and HbA1c (10.78±1.68) were higher in obese group (45.00%) ( P<0.05). Compared with those of the overweight group, the levels of hypertension, disease duration, TG, TC, LDL-C, HbA1c and BMI in the obese group were higher ( P<0.05). The levels of serum 25 (OH) D3 [ (40.25±3.35) mmol/L, (33.18±2.78) mmol/L] in overweight and obese group were lower than those in the normal group ( P<0.05), and the incidence of diabetic vascular complications was 65.22% and 87.50%, respectively, higher than those in the normal group ( P<0.05). Compared with that in the overweight group, serum 25 (OH) D3 level was lower in the obese group ( P<0.05), and the incidence of diabetic vascular complications was higher ( P<0.05). Spearman correlation analysis showed that disease duration, TG, TC, HbA1c were positively correlated with diabetic vascular complications ( P<0.05), and 25 (OH) D3 was negatively correlated with diabetic vascular complications ( P<0.05). Logistic regression analysis showed that disease duration and HbA1c level were risk factors for diabetic vascular complications in the three groups ( P<0.05), while TG, TC and low 25 (OH) D3 were risk factors for diabetic vascular complications in the hyperrecombination and obesity groups ( P<0.05) . Conclusion:The level of 25 (OH) D3 in overweight/obese T2DM patients is negatively correlated with vascular complications of diabetes, and vitamin D supplementation should be paid attention to overweight/obese T2DM patients to reduce the risk of vascular complications of diabetes.
