Prognostic significance of postoperative pulmonary complication and anastomotic leakage after neoadjuvant therapy for esophageal cancer
10.13431/j.cnki.immunol.j.20240038
- VernacularTitle:新辅助治疗后食管癌术后肺部并发症和吻合口瘘的预后意义
- Author:
Zhengdao WEI
1
,
2
;
Jianfeng ZHOU
;
Yushang YANG
;
Hanlu ZHANG
;
Yifeng ZHENG
;
Shijun LIAO
;
Longqi CHEN
Author Information
1. 610041 成都,四川大学华西医院胸外科
2. 610000 成都,西部战区总医院胸外科
- Keywords:
Esophageal cancer;
Neoadjuvant therapy;
Pulmonary complications;
Anastomotic leakage;
Prognosis
- From:
Immunological Journal
2024;40(3):295-302
- CountryChina
- Language:Chinese
-
Abstract:
Postoperative pulmonary complications and anastomotic leakage are unfavorable prognostic factors in patients with esophageal carcinoma.However,the prognostic importance of pulmonary complications and anastomotic leakage after neoadjuvant treatment in these patients remains unclear.This study aimed to determine the effect of postoperative pulmonary complications and anastomotic leakage on long-term survival after neoadjuvant therapy for esophageal cancer.Our study were recruited 441 consecutive patients who had curative resection following neoadjuvant treatment for esophageal cancer in our institution from 2011-2021.The clinicopathological characteristics and prognosis of these patients were studied in terms of postoperative pulmonary complications and anastomotic leaking.Survival was analyzed using the log-rank test and multivariable Cox regression analysis.Postoperative pulmonary complications and anastomotic leakage were present in 23.8％(n=105)and 5.2％(n=23)of esophageal cancer after neoadjuvant therapy,respectively.In the univariate analyses,pulmonary complications were associated with shorter disease-free survival,while anastomotic leakage was associated with shorter overall survival.Multivariable analysis revealed that pulmonary complications after neoadjuvant therapy were independent adverse prognostic factors for disease-free survival.Taken together,postoperative pulmonary complications and anastomotic leakage ware significantly negatively correlated with disease-free and overall survival,respectively.And the postoperative pulmonary complication is an independent poor prognostic factor of disease-free survival for esophageal cancer following neoadjuvant treatment.
