Lactic acid——a multi-faceted player in immune modulation
10.13431/j.cnki.immunol.j.20240028
- VernacularTitle:乳酸——免疫调控多面手
- Author:
Xinyue WANG
1
;
Xiaoling LI
;
Wenxin GUO
;
Bangguo HUANG
;
Jiaping WANG
;
Li WANG
;
Xiaoling CHEN
Author Information
1. 400038 重庆,陆军军医大学基础医学院学员四大队十四队
- Keywords:
Lactic acid;
Immune regulation;
Chronic inflammation;
Infection;
Tumor
- From:
Immunological Journal
2024;40(2):206-210
- CountryChina
- Language:Chinese
-
Abstract:
As the main product of anaerobic or aerobic glycolysis,lactic acid has long been considered to be only the metabolic waste of this process,but now researches have are gradually revealing that lactic acid,as an important signaling molecule,plays a key immune regulatory role by acting on lactic acid transporters,lactate receptors and intracellular direct sensors in immune cells.In chronic inflammatory diseases,lactic acid helps maintain a pro-inflammatory environment that encourages immune cells to remain at the site of inflammation.In the event of infection,lactic acid impairs host immunity.In the tumor microenvironment(TME),the increase in lactic acid production and the resulting TME acidification promote tumor growth and invasion,and inhibit the body's immune response to tumor antigens.This review focuses on the recent research progress on the role of lactic acid in immune regulation.
