The Effect of Dialysate Flow Rate on Dialysis Adequacy and Fatigue in Hemodialysis Patients.
10.4040/jkan.2016.46.5.642
- Author:
Sun Mi CHA
1
;
Hye Sook MIN
Author Information
1. Artificial Kidney Unit, Bethesda Hospital, Yangsan, Korea.
- Publication Type:Original Article
- Keywords:
Renal Dialysis;
Hemodialysis Solutions;
Treatment Outcome;
Urea;
Fatigue
- MeSH:
Dialysis*;
Fatigue*;
Hemodialysis Solutions;
Humans;
Prospective Studies;
Renal Dialysis*;
Treatment Outcome;
Urea
- From:Journal of Korean Academy of Nursing
2016;46(5):642-652
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In this single repeated measures study, an examination was done on the effects of dialysate flow rate on dialysis adequacy and fatigue in patients receiving hemodialysis. METHODS: This study was a prospective single center study in which repeated measures analysis of variance were used to compare Kt/V urea (Kt/V) and urea reduction ratio (URR) as dialysis adequacy measures and level of fatigue at different dialysate flow rates: twice as fast as the participant’s own blood flow, 500 mL/min, and 700 mL/min. Thirty-seven hemodialysis patients received all three dialysate flow rates using counterbalancing. RESULTS: The Kt/V (M±SD) was 1.40±0.25 at twice the blood flow rate, 1.41±0.23 at 500 mL/min, and 1.46±0.24 at 700 mL/min. The URR (M±SD) was 68.20±5.90 at twice the blood flow rate, 68.67±5.22 at 500 mL/min, and 70.11±5.13 at 700 mL/min. When dialysate flow rate was increased from twice the blood flow rate to 700 mL/min and from 500 mL/min to 700 mL/min, Kt/V and URR showed relative gains. There was no difference in fatigue according to dialysate flow rate. CONCLUSION: Increasing the dialysate flow rate to 700 mL/min is associated with a significant nicrease in dialysis adequacy. Hemodialysis with a dialysate flow rate of 700 mL/min should be considered in selected patients not achieving adequacy despite extended treatment times and optimized blood flow rate.
