Corticobasal Degeneration Presenting as Non-Fluent/Agrammatic Primary Progressive Aphasia: A Case Report.
10.12779/dnd.2016.15.2.55
- Author:
Ji Sun KIM
1
;
Geum Bong LEE
;
Yun Jeong HONG
;
Kyung Won PARK
Author Information
1. Department of Neurology, Cognitive Disorders and Dementia Center, College of Medicine, Dong-A University, Busan, Korea. neuropark@dau.ac.kr
- Publication Type:Case Report
- Keywords:
non-fluent agrammatic primary progressive aphasia;
taupathy;
corticobasal degeneration
- MeSH:
Aphasia, Primary Progressive*;
Apraxias;
Dementia;
Female;
Humans;
Memory;
Middle Aged;
Neuroimaging;
Parkinsonian Disorders;
Phenotype;
Supranuclear Palsy, Progressive
- From:Dementia and Neurocognitive Disorders
2016;15(2):55-58
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Non-fluent agrammatic primary progressive aphasia (naPPA) is characterized by progressive non-fluent speech disorder and might be associated with taupathy such as corticobasal degeneration (CBD) and progressive supranuclear palsy. We report a case of overlap syndrome presented with language impairment, and diagnosed as naPPA with possible CBD. CASE REPORT: A 58-year-old woman visited a memory and dementia clinic, with a 10-month history of progressive language disturbance. She was diagnosed as naPPA and overlapping CBD, based on the clinical features and neuroimaging findings including florbetaben PET. CONCLUSIONS: naPPA is pathologically caused by taupathy, and might progress to asymmetrical parkinsonism and apraxia, suggestive of CBD. Overlapping clinical features in our case represent various phenotypes of taupathy.
