Application of immunohistochemistry MYB and Notch1 in adenoid cystic carcinoma of the breast
10.13315/j.cnki.cjcep.2024.09.009
- VernacularTitle:免疫组化MYB和Notch1在乳腺腺样囊性癌中的应用
- Author:
Xiaohong ZHANG
1
;
Xiaoli ZHANG
;
Zhiyong WEI
;
Xiaoying WANG
;
Yiqun SUI
;
Xiaojiang LIU
;
Zhihui WANG
;
Shaobo YAO
;
Mei XUE
Author Information
1. 临沂市肿瘤医院病理科,临沂 276000
- Keywords:
breast neoplasm;
C-AdCC;
SB-AdCC;
MYB;
Notch1
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(9):942-947
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the value of MYB and Notch1 immunohistochemical staining in the differential diagno-sis of classic adenoid cystic carcinoma of the breast(C-AdCC)and solid-basaloid adenoid cystic carcinoma of the breast(SB-AdCC).Methods MYB and Notch1 immunohistochemical staining were performed in 20 cases of C-AdCC,6 cases of SB-AdCC and 65 cases of other breast lesions in the archives of pa-thology department.26 cases of AdCC were detected by FISH,and 6 cases of SB-AdCC were detected by NGS.Results MYB immunohistochemical staining showed that C-AdCC(20/20)was moderately or strongly positive,while SB-AdCC(4/6)was mod-erately or strongly positive.Collagenous spherulosis(5/5)showed focal or diffuse weak positivity;Malignant adenomyoepi-thelioma(3/3)was focally moderately or strongly positive;8 matrix-producing carcinomas and 9 secretory carcinomas and 40 non-specific triple-negative breast cancers were negative.Immu-nohistochemistry of Notch1 showed diffuse moderate positive for SB-AdCC(3/6)and negative for C-AdCC(20/20).3 cases of malignant adenomyoepithelioma,5 cases of collagenous spherulo-sis,8 cases of matrix-producing carcinoma,9 cases of secretory carcinoma and 40 cases of non-specific triple-negative breast cancer were negative.FISH showed MYB gene disruption in C-AdCC(12/19)and NGS showed SB-AdCC(3/6)Notch1 muta-tion.Conclusion Moderately or strongly diffuse expression of MYB and Notch1 by immunohistochemistry can assist in the dif-ferentiation of C-AdCC from SB-AdCC,and it can be further clarified by molecular detection when it is difficult to distinguish malignant adenomyoepithelioma.
