Relationship between tumor-infiltrating lymphocytes,PD-1 and PD-L1 expression with the prognosis of peritoneal mesothelioma
10.13315/j.cnki.cjcep.2024.08.010
- VernacularTitle:腹膜间皮瘤中TILs、PD-1和PD-L1的表达与预后的关系
- Author:
Yue CHEN
1
;
Xuemei DU
;
Zhonghe JI
;
Ying GAO
;
Zhiran YANG
;
Huamin QIN
Author Information
1. 首都医科大学附属北京世纪坛医院病理科,北京 100038
- Keywords:
peritoneal mesothelioma;
TILs;
immune system;
prognosis;
asbestos
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(8):828-833
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the relationship be-tween the expressions of CD3,CD4,CD8,CD20,CD68,PD-1 and PD-L1 and the clinical prognosis of peritoneal mesothelioma(PM).Methods Clinical data of 69 PM patients were collect-ed.EnVision two-step immunohistochemical method was used to detect the expression of CD3,CD4,CD8,CD20,CD68,PD-1 and PD-L1 in PM.Associations between expression levels and survival were estimated by univariate and multivariate Cox pro-portional-hazards models.Results There were no significant differences in the expressions of CD3,CD4,CD8,CD20,CD68,and PD-1 in tumor infiltrating lymphocytes(TILs)of ep-ithelioid and non-epithelioid PM.The expression of PD-L1 in non-epithelioid PM TILs was higher than that in epithelioid PM TILs,but the difference was not statistically significant.The median overall survival(mOS)time of PM was 19.1 months.Multivariate models identified asbestos exposure(P=0.002),PCI score(P=0.034),histological type(P=0.036),and CD4 expression(P=0.043)was independent prognostic factors for PM.Conclusion Asbestos exposure,PCI score,histologi-cal type and CD4 expression in TILs may exert significant im-pacts on survival of PM patients.
