Angiomatoid fibrous histiocytoma:a clinicopathologic study of fourteen cases
10.13315/j.cnki.cjcep.2024.08.008
- VernacularTitle:血管瘤样纤维组织细胞瘤14例临床病理学观察
- Author:
Baofeng YANG
1
;
Libing FU
;
Nan ZHANG
;
Xingfeng YAO
;
Jiatong XU
;
Xiaoxing GUAN
;
Jianwen WANG
;
Lejian HE
Author Information
1. 首都医科大学附属北京儿童医院病理科,北京 100045
- Keywords:
soft tissue neoplasms;
angiomatoid fibrous histiocy-toma;
diagnosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(8):818-823
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the clinical and pathological features of angiomatoid fibrous histocytoma(AFH)and to ex-plore its diagnosis,differential diagnosis and prognosis.Meth-ods The clinicopathological and follow-up data were analyzed in 14 cases of AFH,and the literatures were reviewed.Results There were 11 males and 3 females.The age ranged from 11 months to 12 years and 11 months,with average 5.9 years.3 cases were located in limbs,and 5 cases in trunk,5 cases in head and neck region,and 1 of intracranial tumor.Histological-ly,14 cases were composed of fibrous capsules and lymphocyte sheaths,and cell nucleus were vacuolar,forming fascicles with focal whirling and synteny.Intralesional pseudoangiomatous spaces were noted in 9 cases.Calcification was found in 2 ca-ses.2 cases showed high mitotic acticity(11/10 HPF).Scle-rosing and/or myxoid stroma was seen in 3 cases.Tumors were immunopositive for desmin(10/14),EMA(12/14),CD99(12/14),SMA(9/12),ALK(7/8),and the average of Ki67 index was 16％.7 cases harbored EWSR1 rearrangenent(part-ner gene not identified),2 cases had EWSR1-ATF1 fusion and 2 EWSR1-CREB1 fusion.Clinical follow-up information was a-vailable for 14 cases(average 46 months).All the 14 cases were alive without recurrence and metastasis.Conclusion AFH is a borderline or low-grade malignant tumor,often demon-strates indolent behavior in children,but rarely recurs and me-tastasizes.The diagnosis and differential diagnosis require a comprehensive analysis of clinical features,histopathologic changes,immunohistochemical finding and EWSR1 or FUS gene detection results.
