Plasmablastic lymphoma:clinical and pathological features of 9 cases
10.13315/j.cnki.cjcep.2024.07.014
- VernacularTitle:浆母细胞性淋巴瘤9例临床病理特征分析
- Author:
Zhenhong PU
1
;
Huiling LIANG
;
Wenxiu YANG
;
Jianglong FENG
;
Yuanyuan PEI
Author Information
1. 贵州医科大学附属医院病理科,贵阳 550004
- Keywords:
plasmablastic lymphoma;
HIV;
EBER;
immuno-histochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(7):736-739
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological features,treatment,prognosis and differential diagnosis of plas-mablastic lymphoma(PBL).Methods Collect clinical data of 9 cases of PBL,use HE and immunohistochemistry EnVision staining,detect EB virus using in situ hybridization,detect B lymphocyte gene rearrangement using PCR,analyze its clinical and pathological characteristics,and review relevant literature.Results Among the 9 patients,there were 7 males and 2 fe-males,with a median age of 54 years.Two cases were found in the nasal cavity and sinuses,two cases in the lymph nodes,one cases in the gum,one cases in the tonsil,one cases in the skin,one in the colon and one in the anal canal.Among the 9 cases,4 were HIV positive.The skin lesions are plasma like cells,and the remaining areas are plasma like/immune like cells.Immuno-phenotype:CD138,MUM1 and C-myc were all positive.CD20,CD3 and CD5 were negative.Some of them expressed CD38(7/8),CD79a(6/9),CD56(3/7)and PAX5(1/8).Ki67 prolif-eration index was high(70％-95％).EBER in situ hybridiza-tion was positive in 8 cases.Conclusion The diagnosis of PBL is difficult and requires a combination of clinical manifestations,histological features,immunophenotype,and molecular patholo-gy to make the final diagnosis.The prognosis of PBL is very poor and there are no effective treatment options.
