Expression of ORAOV1 and ERK and their relationship to clinical features and prognosis in esophageal squamous cell carcinoma
10.13315/j.cnki.cjcep.2024.06.010
- VernacularTitle:ORAOV1与ERK在食管鳞状细胞癌中的表达及与临床特征、预后的关系
- Author:
Wenli CHANG
1
;
Ning DU
;
Shasha WANG
;
Nana WANG
;
Qing CHU
;
Qian ZHANG
Author Information
1. 滨州医学院第一临床学院病理科,滨州 256600
- Keywords:
esophageal neoplasms;
squamous cell carcinoma;
ORAOV1;
ERK;
prognosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2024;40(6):609-614
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological significance and prognostic value of oral cancer overexpressed 1(ORAOV1)in esophageal squamous cell carcinoma(ESCC).Methods The mRNA expression of ORAOV1,ERK1 and ERK2 in 140 ESCC and 39 esophageal squamous intraepithelial neoplasia(ESIN)and 140 adjacent normal mucosal tissues were detected by RT-PCR.The relationship between their overexpres-sion and clinicopathological features was analyzed in ESCC pa-tients.Spearman correlation analysis was used to explore the correlation between ORAOV1 and ERK1 and ERK2.Results The expression level of ORAOV1 mRNA(13.158±2.246)with ESCC was significantly higher than that of low-grade ESIN(4.974±1.317),high-grade ESIN(7.398±1.891)and adja-cent tissues(1.000±0).The differences were significant(P＜0.01).High expression of ORAOV1 mRNA was positively cor-related with ESCC clinical stage and lymph node metastasis(all P＜0.05).Spearman analysis showed that the expression level of ORAOV1 mRNA was positively correlated with the expression levels of ERK1 mRNA and ERK2 mRNA in ESCC.Kaplan-Meier survival curve analysis showed that the overall survival of ESCC patients with high expression of ORAOV1 was significantly lower than that of patients with low expression,and the differ-ence was significant(P＜0.05).Conclusion The expression level of ORAOV1 gradually increases during the occurrence and development of ESCC,which is an independent prognostic factor of ESCC and is expected to become a new molecular target for early diagnosis and treatment of ESCC.
