Clinicopathological features of fibrin-a ssociated diffuse large B cell lymphoma arising within concurrent atrial myxoma: report of six cases
10.3760/cma.j.cn112151-20200302-00160
- VernacularTitle:心房黏液瘤伴纤维素相关弥漫性大B细胞淋巴瘤六例临床病理学特征
- Author:
Jinhai YAN
1
;
Donglan LUO
;
Fen ZHANG
;
Yu CHEN
;
Xinlan LUO
;
Jie XU
;
Zhi LI
;
Yanhui LIU
Author Information
1. 广东省人民医院 广东省医学科学院病理医学部病理科，广州 510080
- Keywords:
Heart neoplasms;
Myxoma;
Cellulose;
Lymphoma, large B-cell, diffuse;
Herpesvirus 4, human
- From:
Chinese Journal of Pathology
2020;49(10):1027-1030
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological features, treatment and prognosis of fibrin-associated diffuse large B cell lymphoma (DLBCL) arising within concurrent atrial myxoma.Methods:Six cases of fibrin-associated DLBCL arising within concurrent atrial myxoma diagnosed at the Department of Pathology, Guangdong General Hospital, from 2006 to 2019 were included. The histology, immunophenotype, treatment and prognoses were analyzed.Results:The patients′ age ranged from 46 to 78 years (mean 59 years). There were 3 males and 3 females. The tumors were all discovered incidentally on histological examination of surgical pathology specimens excised for atrial myxoma. All patients appeared to have morphological features of DLBCL, B lineage immunophenotype, high proliferative index and latency type III of Epstein-Barr viral infection. They had complete tumor resections without adjuvant chemotherapy and were healthy at 5- to 120-month follow-ups.Conclusions:Fibrin-associated DLBCL arising within concurrent atrial myxoma is an unusual form of DLBCL associated with chronic inflammation, and its clinical outcome is indolent. The findings suggest that this type of lymphoma does not warrant excessive or unnecessary treatments after complete resection.
