Expression of SOX-11 and TFE3 in solid-pseudopapillary tumor of pancreas and its clinical significance
10.3760/cma.j.cn112151-20191215-00800
- VernacularTitle:SOX-11及TFE3在胰腺实性假乳头状肿瘤中的表达及其临床意义
- Author:
Ya WANG
1
;
Yao FU
;
Zhong ZHENG
;
Hongyan WU
;
Qiang ZHOU
;
Kongling CHEN
;
Yu TAO
;
Xiaohong PU
;
Jie DING
;
Ting WANG
;
Jiong SHI
;
Xiangshan FAN
Author Information
1. 南京大学医学院附属鼓楼医院病理科 210008
- Keywords:
Pancreatic neoplasms;
SOXC transcription factors;
Diagnosis, differential;
Solid pseudopapillary tumor;
TFE3
- From:
Chinese Journal of Pathology
2020;49(10):1036-1040
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression status and diagnostic value of SRY related high mobility group box 11 (SOX-11) and transcription factor E-3 (TFE3) in solid pseudopapillary tumors of pancreas (SPTPs).Methods:Thirty-eight cases of SPTPs, 36 cases of well-differentiated pancreatic neuroendocrine tumors (PanNETs) and six cases of pancreatic acinar cell carcinomas (PACCs) were collected at the Affiliated Drum Tower Hospital of Nanjing University Medical School from 2012 to 2019. The expression of SOX-11, TFE3 and β-catenin was detected by immunohistochemistry, and the TFE3 gene status was detected by FISH in 18 cases of SPTPs.Results:Among the 38 SPTP patients, 29 were female and 9 were male, with a mean age of 50 years; among 36 PanNET patients, 32 were female and 4 were male, with a mean age of 39 years; for the six PACC patients, four were male and two were female, with a mean age of 60 years. β-catenin was positive in all 38 SPTPs, but was negative in all 36 PanNETs and 5/6 PACCs. SOX-11 was positive in 35/38 (92.1%) of SPTPs, but was negative in all 36 PanNETs and 6 PACCs. TFE3 was positive in 36/38 (94.7%) of SPTPs, but was negative in all 36 PanNETs and 6 PACCs. Among these three tumors, the specificity and sensitivity of β-catenin were 97.6% and 100.0%, the specificity and sensitivity of SOX-11 were 92.1% and 100.0%, the specificity and sensitivity of TFE3 were 94.7% and 100.0%, respectively. There was a significant difference of the expression status of all three markers in SPTPs compared with PanNETs and PACCs ( P<0.01). The results of SOX-11 and TFE3 immunostaining showed high consistency (Kappa>0.6). No gene rearrangement (0/18) of TFE3 was found in SPTPs. Conclusion:SOX-11 and TFE3 are highly expressed in SPTPs, and their specificity in the differential diagnosis of SPTPs is better than that of β-catenin.
