New advances in ex vivo mechanical perfusion treatment for kidneys
10.3969/j.issn.1005-6483.20241685
- VernacularTitle:肾脏离体机械灌注治疗新进展
- Author:
Ziguo LIN
1
;
Yunhao WANG
;
Yanfeng WANG
Author Information
1. 430071 武汉大学中南医院,武汉大学肝胆疾病研究院,武汉大学移植医学中心,移植医学技术湖北省重点实验室
- Keywords:
kidney transplantation;
ex vivo machine perfusion;
hypothermic mechanical perfusion;
normothermic mechanical perfusion
- From:
Journal of Clinical Surgery
2024;32(11):1222-1225
- CountryChina
- Language:Chinese
-
Abstract:
Kidney transplantation remains the gold standard treatment for patients with end-stage renal disease.To address the growing demand for organs,there is an increasing reliance on organs from donors after cardiac death(DCD)and expanded criteria donors(ECD).These marginal organs are at a heightened risk of severe ischemia-reperfusion injury,which can lead to a higher incidence of primary nonfunction,delayed graft function,and reduced long-term graft survival rates following transplantation.Ex vivo machine perfusion(EVMP)provides superior protection for donor kidneys compared to traditional static cold storage.Additionally,EVMP can serve as a platform for the dynamic administration of drugs or gene therapies,further enhancing the efficacy of kidney transplantation.This review outlines innovative strategies for ex vivo kidney mechanical perfusion treatments,including mesenchymal stem cell therapy,gene therapy,nanotechnology,anti-infectives,gas therapy,thrombolytics,blood type conversion,and other therapeutic approaches.
