The expression of p53 protein and its clinicopathological features and prognosis of esophageal spindle cell carcinoma
10.3760/cma.j.cn112151-20200106-00014
- VernacularTitle:食管梭形细胞癌p53蛋白的表达与临床病理特征及预后分析
- Author:
Lulu RONG
1
;
Liyan XUE
;
Xuemin XUE
;
Jin LI
;
Ning LYU
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院 北京协和医学院 肿瘤医院病理科 100021
- Keywords:
Esophageal neoplasms;
Carcinosarcoma;
Tumor suppressor protein p53;
Prognosis
- From:
Chinese Journal of Pathology
2020;49(7):715-720
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association of p53 protein expression with clinicopathological features and prognosis in esophageal spindle cell carcinoma.Methods:A total of 4 439 esophageal squamous cell carcinoma (ESCC) patients who underwent radical esophagectomy without neoadjuvant therapy between May 2010 and May 2019 were included. The HE slides and clinicopathological parameters were reviewed. Among these, there were 63 cases of esophageal spindle cell carcinoma; p53 protein expression was evaluated by immunohistochemistry (IHC) and its correlation with clinicopathological parameters and patients′ outcome was analyzed.Results:The 63 esophageal spindle cell carcinoma accounted for 1.4% (63/4 439) of all ESCC. Of the 63 patients there were 55 males and 8 females, male to female ratio was 7∶1. The p53 protein mutation expression rate was 77.8% (49/63), including 14 cases with wild-type expression, 22 with nonsense mutation expression, and 27 with missense mutation expression. The concordance rate of p53 protein expression between carcinoma components and spindle cell components was 100%. Survival analysis showed that p53 protein mutation expression was significantly correlated with overall survival (OS, P=0.044), patients with p53 protein mutation expression had poorer OS. Conclusion:p53 protein expression is highly concordant in the squamous cell carcinoma components and spindle cell components of esophageal spindle cell carcinoma; its mutation expression is associated with poor outcome of the patients.
